Calpain Inhibitor IV (MG132)

1 mg

Artikelnummer:PPI 3710-1MG
Menge:
Technische Daten
Format Peptide:white solid
Lagerung Peptide:-20 °C
Löslichkeit:1 mg/ml in ethanol
Molekulargewicht:475.63
Qualitätskontrolle:Analysis by HPLC
Reinheit (HPLC):> 97 %
Summenformel:C26H41N3O5
Target:Proteasome, Calpain
CAS Nr.:133407-82-6
Stabilität:Lyoph.: 24 months, if stored dry and protected from light
Klasse:Cysteine protease inhibitor
Synonyme:Z-Leu-Leu-Leu-al
Verfügbar in folgenden Ländern:world wide
Beschreibung

A potent, reversible, and cell-permeable proteasome inhibitor. Initiates neurite outgrowth in PC12 cells with an optimal concentration of 10 µM. Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Blocks cleavage of poly(ADP-ribose) polymerase and apoptosis in thymocytes. It activates JNK-1, responsible for apoptosis initiation in response to cell stress.

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