p53

DO7, Ms, 0.1 ml Conc.

Artikelnummer:1-P5001-02
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:DO7
Spezies:Mouse
Ig Unterklasse:IgG2b/k
Immunogen:p53 Protein
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Kontrolle:Breast carcinoma, colon carcinoma
Lagerung AK:Aliquot and store at - 20 °C. Do not use after expiration date indicated on the vial.
Zelluläre Lokalisation:Nuclear
Synonyme:Antigen NY-CO-13, Cellular tumor antigen p53, FLJ92943, LFS1, p53 tumor suppressor, Phosphoprotein p53, TP53, Transformation related protein 53, TRP53, Tumor protein p53, Tumor suppressor p53
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

p53 protein is a tumor suppressor that induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is expressed ubiquitous; isoforms are expressed in a wide range of normal tissues. Mutation and/or allelic loss of p53 gene is one of the causes of the occurrence of a variety of mesenchymal and epithelial tumors. This antibody recognizes a 53 kDa phosphoprotein, it reacts with the mutant as well as wildtype form of p53. Positive nuclear staining with this antibody is a negative prognostic factor in carcinoma of breast, lung, colon, and urothel; and it helps to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. p53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution.

Literatur

[1] Lakin ND and Jackson SP (1999): Regulation of p53 in response to DNA damage. Oncogene. 18(53):7644-55.
[2] Levine AJ (1997): p53, the cellular gatekeeper for growth and division. Cell. 88(3):323-31.

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