p53

Rb, 1 ml RTU

Artikelnummer:2-P5003-07
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Kontrolle:Colon cancer
Zelluläre Lokalisation:Nuclear
Fixierung:1) NOTOXhisto 2) Formalin
Anwendung AK:IHC(p)
Immunogen:Synthetic peptide of human p53
Ig Unterklasse:IgG
Spezies:Rabbit
Klon:Polyclonal
Format AK:Ready-to-use
Reaktivität AK:Human, others not tested.
Synonyme:aifm2, AIFM2_HUMAN, AMID, Apoptosis inducing factor (AIF) homologous mitochondrion associated inducer of death, Apoptosis inducing factor (AIF) like mitochondrion associated inducer of death, Apoptosis inducing factor mitochondrion associated 2, Apoptosis-inducing factor 2, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, Apoptosis-inducing factor-like mitochondrion-associated inducer of death, Cys51Stop, p53 responsive gene 3 p53 tumor suppressor p53-responsive gene 3 protein PRG3 TRP53 Tumor protein p53.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

p53 protein is a tumor suppressor that induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is expressed ubiquitous; isoforms are expressed in a wide range of normal tissues. Mutation and/or allelic loss of p53 gene is one of the causes of the occurrence of a variety of mesenchymal and epithelial tumors. This antibody recognizes a 53 kDa phosphoprotein, it reacts with the mutant as well as wildtype form of p53. Positive nuclear staining with this antibody is a negative prognostic factor in carcinoma of breast, lung, colon, and urothel; and it helps to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. p53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution.

Literatur

[1] Lakin ND and Jackson SP (1999): Regulation of p53 in response to DNA damage. Oncogene. 18(53):7644-55.
[2] Levine AJ (1997): p53, the cellular gatekeeper for growth and division. Cell. 88(3):323-31.

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