hnRNP K

Rb

Artikelnummer:HE134-H_RUO
Menge:
Technische Daten
Status:Research Use Only (RUO)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human hnRNP K
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Cytoplasmic, nuclear, translocates to the nucleus during heat shock
Kontrolle:Hepatocellular carcinoma
Change(s) made:Complete revision
Synonyme:CSBP, dC stretch binding protein, FLJ41122 antibody Heterogeneous nuclear ribonucleoprotein K, hnRNP K, HNRNPK, HNRPK, HNRPK_HUMAN, Transformation up regulated nuclear protein, Transformation up-regulated nuclear protein, Transformation upregulated nuclear protein, TUNP.
Verfügbar in folgenden Ländern:worldwide
Beschreibung

Heterogeneous nuclear ribonucleoprotein K (also protein K) is a protein that is found in the cell nucleus and binds to pre-messenger RNA (mRNA) as a component of heterogeneous ribonucleoprotein particles. Binding to single-stranded DNA as well as to RNA and can stimulate the activity of RNA polymerase II, the protein responsible for most gene transcription. Protein K has been the subject of study related to colorectal cancer. Deletions in the region encompassing HNRNPK have been found in the cells of acute myeloid leukemia in approximately 2 % of cases. Additionally, a majority of mice who have had one of their HNRNPK genes artificially knocked out developed myeloid cancers, with a third developing lymphoid cancers and 4 % developing hepatocellular carcinomas. HNRNPK overexpression also appears to contribute to cancers via a different mechanism involving translation rather than transcription.

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