c-Myc

Rb, 0.5 ml Conc.

Artikelnummer:1-C0032-05
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Kontrolle:Human skin carcinoma
Zelluläre Lokalisation:Nuclear
Fixierung:1) NOTOXhisto 2) Formalin
Anwendung AK:IHC(p),IHC(f)
Immunogen:Synthetic peptide of human C-Myc N-terminal
Ig Unterklasse:IgG
Spezies:Rabbit
Klon:Polyclonal
Format AK:Concentrate
Reaktivität AK:Human, others not tested.
Synonyme:AU016757, Avian myelocytomatosis viral oncogene homolog, bHLHe39, c Myc, Cellular myelocytomatosis oncogene, MGC105490, MRTL, Myc protein, Myc proto oncogene protein, Myc-related translation/localization regulatory factor, Myc2, myca, Myelocytomatosis oncogene a, Myelocytomatosis oncogene, Niard, Nird, Oncogene Myc, Protooncogene homologous to myelocytomatosis virus, RNCMYC, Transcription factor p64, Transcriptional regulator Myc-A, v myc avian myelocytomatosis viral oncogene homolog, v myc myelocytomatosis viral oncogene homolog (avian), V-Myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog (avian), zc-myc.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

c-Myc is a transcription factor that is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. Overexpression of Myc is implicated in a variety of hematopoietic tumors, and defects may be a cause of a form of B-cell chronic lymphocytic leukemia.

Literatur

[1] Jacobson C and LaCasce A (2014): How I treat Burkitt lymphoma in adults. Blood. 124(19): 2913-2920.
[2] Mundim FG, Pasini FS, Brentani MM et al. (2015): MYC is expressed in the stromal and epithelial cells of primary breast carcinoma and paired nodal metastases. Mol Clin Oncol. 3(3): 506-514.
[3] Xu M, Liu Q, Jia Y et al. (2016): BCAT1 promotes tumor cell migration and invasion in hepatocellular carcinoma. Oncol Lett. 12(4): 2648-2656.
[4] He C, Jiang H, Geng S et al. (2012): Expression of c- Myc and Fas correlates with perineural invasion of pancreatic cancer. Int J Clin Exp Pathol. 5(4): 339-346.
[5] Yang G, Goltsov AA, Ren C et al. (2012): Caveolin-1 upregulation contributes to c-Myc-induced high-grade prostatic intraepithelial neoplasia and prostate cancer. Mol Cancer Res. 10(2): 218-229.

Kontakt