ZAP-70

Rb, 1 ml Conc.

Artikelnummer:1-ZA002-07
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Zelluläre Lokalisation:Cytoplasmic, nuclear
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human ZAP-70
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Kontrolle:Tonsil, chronic lymphocytic leukemia
Synonyme:zeta-associated protein 70, ZAP70, ZAP-70=protein tyrosine kinase Syk homolog {SH2-like and C-terminal kinase domains}, Tyrosine-protein kinase ZAP-70, 70 kDa zeta-associated protein, Syk-related tyrosine kinase. SRK, STD, TZK.
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

ZAP-70 is a 70 kD protein of tyrosine kinase found in T-cells and natural killer cells. ZAP-70 is useful for the identification of a subset of chronic lymphocytic leukemias (CLL). In CLL, the ZAP-70 expression is closely associated with an unmutated configuration of the immunoglobulin heavy-chain variable region (IgVH) genes. ZAP-70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (ZAP-70 negative) and Ig-unmutated (ZAP-70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The ZAP-70 positive Ig-unmutated CLL cases have a poorer prognosis.

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