ZAP-70

2F3.2, Ms

Artikelnummer:ZA001-H
Menge:
Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Spezies:Mouse
Ig Unterklasse:IgG2a/k
Immunogen:ZAP-70
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Lymph node, chronic lymphocytic leukemia, tonsil
Synonyme:zeta-associated protein 70, ZAP70, ZAP-70=protein tyrosine kinase Syk homolog {SH2-like and C-terminal kinase domains}, Tyrosine-protein kinase ZAP-70, 70 kDa zeta-associated protein, Syk-related tyrosine kinase. SRK, STD, TZK.
Verfügbar in folgenden Ländern:worldwide
Beschreibung

ZAP-70 is a 70 kD protein of tyrosine kinase found in T-cells and natural killer cells. ZAP-70 is useful for the identification of a subset of chronic lymphocytic leukemias (CLL). In CLL, the ZAP-70 expression is closely associated with an unmutated configuration of the immunoglobulin heavy-chain variable region (IgVH) genes. ZAP-70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (ZAP-70 negative) and Ig-unmutated (ZAP-70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The ZAP-70 positive Ig-unmutated CLL cases have a poorer prognosis.

Literatur

Kontakt