63.7, Ms

Technische Daten
Change(s) made:Complete revision
Status:Research Use Only (RUO)
Ig Unterklasse:IgG2a
Immunogen:Recombinant YAP
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear, cytoplasmic
Kontrolle:Breast, breast cancer
Synonyme:65 kDa Yes associated protein, 65 kDa Yes-associated protein, COB1, YAp 1, YAP 65, YAP, YAP-1, YAP1, YAP1_HUMAN, YAP2, YAP65, yes -associated protein delta, Yes associated protein 1 65kDa, Yes associated protein 1, Yes associated protein 2, yes associated protein beta, YKI, Yorkie homolog
Verfügbar in folgenden Ländern:worldwide

YAP is a transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. YAP is expressed at high levels in the lung, placenta, prostate, ovary and testis. Increased expression is seen in some liver and prostate cancers.