Wilms tumor 1/WT1
Rb, 1 ml RTU
Technische Daten
| Reaktivität AK: | Human, others not tested. | | Format AK: | Ready-to-use | | Klon: | Polyclonal | | Spezies: | Rabbit | | Ig Unterklasse: | IgG | | Immunogen: | Synthetic peptide of human Wilms Tumor Protein | | Anwendung AK: | IHC(p),IHC(f) | | Fixierung: | 1) NOTOXhisto 2) Formalin | | Zelluläre Lokalisation: | Nuclear | | Kontrolle: | Testes, ovarian carcinoma (non-mucinous carcinoma), malignant mesothelioma | | Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | | Synonyme: | WIT 2,
WT 1,
AWT1,
FWT1,
GUD,
NPHS4,
WAGR,
Wilms tumor 1,
Wilms Tumor,
Wilms tumor protein,
Wilms' tumor gene,
Wilms' tumor protein,
WIT2,
WT,
WT1,
WT1_HUMAN,
WT33. | | Verfügbar in folgenden Ländern: | world wide (except US) | | Status: | IVD |
Beschreibung
Wilms’ Tumor Protein (WT1) is a suppressor gene located on chromosome 11p13, it regulates transcription of other genes and can function both as a transcriptional activator and repressor. The antibody reacts with all isoforms of WT1 and also identifies WT1 lacking exon 2-encoded amino acids.WT1 has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian cystadenocarcinoma, gonadoblastoma, nephroblastoma and desmoplastic small round cell tumor.
Literatur
[1] Hastie ND. (2017) Wilms' tumour 1 (WT1) in
development, homeostasis and disease. Development.
144(16):2862-2872.
[2] Murphy AJ, Pierce J, de Caestecker C et al. (2014)
Aberrant Activation, Nuclear Localization, and
Phosphorylation of Yes-Associated Protein-1 in the
Embryonic Kidney and Wilms Tumor. Pediatr Blood
Cancer. 61(2): 198-205.
[3] Rivera MN, Kim WJ, Wells J et al. (2009) The tumor
suppressor WTX shuttles to the nucleus and modulates
WT1 activity. Proc Natl Acad Sci U S A. 106(20): 8338-
8343.
[4] Silberstein GB, Van Horn K, Strickland P et al. (1997)
Altered expression of the WT1 Wilms tumor suppressor
gene in human breast cancer. Proc. Natl. Acad. Sci. USA.
94(15): 8132-8137.
[5] Wilms M (1899) Die Mischgeschwu_lste. Leipzig :
Verlag von Arthur Georgi.
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