Villin 1

Rb, 1 ml Conc.

Artikelnummer:1-VI004-07
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Zelluläre Lokalisation:Cytoplasmic, membranous
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Kontrolle:Small intestine, colorectal carcinoma
Synonyme:VIL, VIL1, Villin 1, Villin-1, Villin1.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Villin is a calcium-regulated, actin-binding glycoprotein of microvilli which has a certain effect of the actin filament assembly regulation. It is associated with rootlet formation in gastrointestinal mucosal epithelium. The antibody labels the brush border area in the gastrointestinal mucosal epithelium. It can be useful in differentiating gastrointestinal adenocarcinoma, neuroendocrine carcinomas and ovarian adenocarcinomas from adenocarcinomas from other organs.

Literatur

[1] Friederich E, Vancompernolle K, Louvard D and Vandekerckhove J (1999): Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. J Biol Chem. 274(38):26751-60.
[2] George SP, Wang Y, Mathew SJ et al. (2007): Dimerization and actin-bundling properties of villin and its role in the assembly of epithelial cell brush borders. Biol Chem. 282(36):26528-41.
[3] Tan J, Sidhu G, Greco MA et al. (1998): Villin, cytokeratin 7, and cytokeratin 20 expression in pulmonary adenocarcinoma with ultrastructural evidence of microvilli with rootlets. Hum Pathol. 29(4):390-6.
[4] Zhang PJ, Harris KR, Alobeid B and Brooks JJ (1999): Immunoexpression of villin in neuroendocrine tumors and its diagnostic implications. Arch Pathol Lab Med. 123(9):812-6.
[5] Bretscher A and Weber K (1979): Villin: the major microfilament-associated protein of the intestinal microvillus. Proc Natl Acad Sci U S A. 76(5):2321-5.
[6] Kennedy MT, Jordan RC and Berean KWJ (2004): Expression pattern of CK7, CK20, CDX-2, and villin in intestinal-type sinonasal adenocarcinoma. Clin Pathol. 57(9):932-7.

Kontakt