Technische Daten
| Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | | Zelluläre Lokalisation: | Cytoplasmic, membranous | | Reaktivität AK: | Human, others not tested. | | Format AK: | Ready-to-use | | Klon: | Polyclonal | | Spezies: | Rabbit | | Ig Unterklasse: | IgG | | Immunogen: | Synthetic peptide | | Anwendung AK: | IHC(p),IHC(f) | | Fixierung: | 1) NOTOXhisto 2) Formalin | | Kontrolle: | Small intestine, colorectal carcinoma | | Synonyme: | VIL, VIL1, Villin 1, Villin-1, Villin1. | | Verfügbar in folgenden Ländern: | world wide (except US) | | Status: | IVD |
Beschreibung
Villin is a calcium-regulated, actin-binding glycoprotein of microvilli which has a certain effect of the actin filament assembly regulation. It is associated with rootlet formation in gastrointestinal mucosal epithelium. The antibody labels the brush border area in the gastrointestinal mucosal epithelium. It can be useful in differentiating gastrointestinal adenocarcinoma, neuroendocrine carcinomas and ovarian adenocarcinomas from adenocarcinomas from other organs.
Literatur
[1] Friederich E, Vancompernolle K, Louvard D and
Vandekerckhove J (1999): Villin function in the
organization of the actin cytoskeleton. Correlation of in
vivo effects to its biochemical activities in vitro. J Biol
Chem. 274(38):26751-60.
[2] George SP, Wang Y, Mathew SJ et al. (2007):
Dimerization and actin-bundling properties of villin and its
role in the assembly of epithelial cell brush borders. Biol
Chem. 282(36):26528-41.
[3] Tan J, Sidhu G, Greco MA et al. (1998): Villin,
cytokeratin 7, and cytokeratin 20 expression in pulmonary
adenocarcinoma with ultrastructural evidence of microvilli
with rootlets. Hum Pathol. 29(4):390-6.
[4] Zhang PJ, Harris KR, Alobeid B and Brooks JJ (1999):
Immunoexpression of villin in neuroendocrine tumors and
its diagnostic implications. Arch Pathol Lab Med.
123(9):812-6.
[5] Bretscher A and Weber K (1979): Villin: the major
microfilament-associated protein of the intestinal
microvillus. Proc Natl Acad Sci U S A. 76(5):2321-5.
[6] Kennedy MT, Jordan RC and Berean KWJ (2004):
Expression pattern of CK7, CK20, CDX-2, and villin in
intestinal-type sinonasal adenocarcinoma. Clin Pathol.
57(9):932-7.
|
