Villin 1


Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Cytoplasmic, membranous
Kontrolle:Small intestine, colorectal carcinoma
Synonyme:VIL, VIL1, Villin 1, Villin-1, Villin1.
Verfügbar in folgenden Ländern:worldwide

Villin is a tissue-specific actin-binding protein that is associated with the cytoskeleton of the brush border and plays various roles related to actin filaments. The protein is expressed in differentiated epithelial cells with a brush border such as intestinal villi, proximal renal tubules, oviducts and seminal ducts as well as tumors derived from these tissues. Due to its limited expression, the antibody is used to identify gastrointestinal adenocarcinomas as well as renal cell carcinomas, pancreatic carcinomas, endometrial carcinomas and carcinomas of the ovary and lung. In combination with CK7 and CK20, villin can be helpful in the differentiation of colon from lung carcinomas.


[1] Friederich E, Vancompernolle K, Louvard D and Vandekerckhove J (1999): Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. J Biol Chem. 274(38):26751-60.
[2] George SP, Wang Y, Mathew SJ et al. (2007): Dimerization and actin-bundling properties of villin and its role in the assembly of epithelial cell brush borders. Biol Chem. 282(36):26528-41.
[3] Tan J, Sidhu G, Greco MA et al. (1998): Villin, cytokeratin 7, and cytokeratin 20 expression in pulmonary adenocarcinoma with ultrastructural evidence of microvilli with rootlets. Hum Pathol. 29(4):390-6.
[4] Zhang PJ, Harris KR, Alobeid B and Brooks JJ (1999): Immunoexpression of villin in neuroendocrine tumors and its diagnostic implications. Arch Pathol Lab Med. 123(9):812-6.
[5] Bretscher A and Weber K (1979): Villin: the major microfilament-associated protein of the intestinal microvillus. Proc Natl Acad Sci U S A. 76(5):2321-5.
[6] Kennedy MT, Jordan RC and Berean KWJ (2004): Expression pattern of CK7, CK20, CDX-2, and villin in intestinal-type sinonasal adenocarcinoma. Clin Pathol. 57(9):932-7.