Uroplakin III
Rb, 1 ml Conc.
Technische Daten
| Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | | Zelluläre Lokalisation: | Membranous, cytoplasmic | | Reaktivität AK: | Human, others not tested. | | Format AK: | Concentrate | | Klon: | Polyclonal | | Spezies: | Rabbit | | Ig Unterklasse: | IgG | | Immunogen: | Synthetic peptide of human Uroplakin III | | Anwendung AK: | IHC(p),IHC(f) | | Fixierung: | 1) NOTOXhisto 2) Formalin | | Kontrolle: | Urothelial carcinoma, bladder | | Synonyme: | MGC119178 antibody
OTTHUMP00000028951 antibody
UP III antibody
UP3a antibody
UPIII antibody
UPIIIA antibody
UPK 3 antibody
UPK 3A antibody
UPK3 antibody
UPK3A antibody
UPK3A_HUMAN antibody
Uroplakin 3A antibody
Uroplakin III antibody
Uroplakin-3a antibody
Uroplakin3A antibody
UroplakinIII antibody | | Verfügbar in folgenden Ländern: | world wide (except US) | | Status: | IVD |
Beschreibung
Uroplakin III is a 47 kD glycoprotein of the asymmetrical unit. Uroplakin III is a highly specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. It stains the urothelial surface membrane of human renal pelvis, ureter, bladder, and urethra. Studies have also shown Uroplakin III expression was restricted to a subset of p63-negative carcinoma cells, including anaplastic carcinoma cells.
Literatur
[1] Kaufmann O, Volmerig J and Dietel M (2000): Uroplakin III is a highly specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Am J Clin Pathol. 113(5):683-7.
[2] Yuasa T, Yoshiki T, Tanaka T et al. (1998): Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma. Jpn J Cancer Res. 89(9):879-82.
[3] Wu XR, Manabe M, Yu J and Sun TT (1990): Large scale purification and immunolocalization of bovine uroplakins I, II, and III. Molecular markers of urothelial differentiation. J Biol Chem. 265(31):19170-9.
[4] Wu XR and Sun TT (1993): Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein. J Cell Sci. 106 ( Pt 1):31-43.
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