Tyrosinase

Rb, 7 ml RTU

Artikelnummer:2-TY003-13
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Zelluläre Lokalisation:Cytoplasmic
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human Tyrosinase
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Kontrolle:Malignant melanoma, skin
Synonyme:LB24 AB, LB24-AB, Monophenol monooxygenase, SK29 AB, Tumor rejection antigen AB, LB24 AB, Monophenol monooxygenase, OCA1A, OCAIA, Oculocutaneous albinism IA, SK29 AB, SK29-AB, Tumor rejection antigen AB, TYR, tyrosinase (oculocutaneous albinism IA), TYRO_HUMAN.
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

Tyrosinase (monophenol monooxygenase) is an enzyme that is responsible for converting tyrosine into melanin in human melanocytes. The tyrosinase gene is regulated by the Microphthalmia-associated transcription factor (MiTF) gene product. The antibody has been found to be quite specific for melanotic lesions such as malignant melanoma, and melanotic neurofibroma.

Literatur

[1] Chen YT, Stockert E, Tsang S et al. (1995): Immunophenotyping of melanomas for tyrosinase: implications for vaccine development. Proc Natl Acad Sci U S A. 92(18):8125-9.
[2] Clarkson KS, Sturdgess IC and Molyneux AJ (2001): The usefulness of tyrosinase in the immunohistochemical assessment of melanocytic lesions: a comparison of the novel T311 antibody (anti-tyrosinase) with S-100, HMB45, and A103 (anti-melan-A). J Clin Pathol. 54(3):196-200.
[3] Avogadri F, Gnjatic S, Tassello J et al. (2016): Protein Expression Analysis of Melanocyte Differentiation Antigen TRP-2. Am J Dermatopathol. 38(3):201-7.
[4] Jäger E, Ringhoffer M, Altmannsberger M et al. (1997): Immunoselection in vivo: independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma. Int J Cancer. 71(2):142-7.
[5] Sheffield MV, Yee H, Dorvault CC et al. (2002): Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparations. Am J Clin Pathol. 118(6):930-6.
[6] Shidham VB, Qi D, Rao RN et al. (2003): Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with 'MCW melanoma cocktail'--a mixture of monoclonal antibodies to MART-1, Melan-A, and tyrosinase. BMC Cancer. 3:15.

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