Thrombomodulin

Rb

Artikelnummer:CD332-H_RUO
Menge:
Technische Daten
Change(s) made:Complete revision
Status:Research Use Only (RUO)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human Thrombomodulin
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Membranous, cytoplasmic
Kontrolle:Vascular tissue, angiosarcoma
Synonyme:Thrombomodulin, CD 141, CD141, CD141 antigen, Fetomodulin, THBD, THRM, TM.
Verfügbar in folgenden Ländern:worldwide
Beschreibung

CD141, also known as Thrombomodulin, is a type I membrane glycoprotein and forms a 1:1 stoichiometric complex with thrombin, which activates the protein C. The activated protein C splits the activated cofactors of coagulation mechanism, factor Va and VIIIa, thus reduces the amount of thrombin generated. CD141 is expressed on monocyted, macrophages, a subpopulation of myeloid dendritic cells, vascular endothelial cells, and keratinocytes. It is also involved in embryonic and atherosclerotic plaque development.

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