Terminal deoxynucleotidyltransferase/TdT

Rb, 0.1 ml Conc.

Artikelnummer:1-TE027-02
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Zelluläre Lokalisation:Nuclear
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human TdT protein
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Kontrolle:Thymus (TdT positive)
Synonyme:TdT, DNA nucleotidylexotransferase, DNTT
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

TdT is a specialized DNA polymerase that adds N-nucleotides to the V, D, and J exons during antibody gene recombination enabling junctional diversity. It is expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells, it is not expressed in pre-B-Cell ALL and normal mature T-or B-lymphocytes. This antibody detects normal cortical thymocytes and primitive lymphocytes; it detects an enzyme found in the nucleus of normal hematopoietic cells, normal cortical thymocytes and in the cytoplasm of megakaryocytes of the bone marrow. Anti-TdT is positive for approximately one third of all cases of chronic myeloid leukemia, making it a good indicator of better response to chemotherapy.

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