Terminal deoxynucleotidyltransferase/TdT

Rb, 7 ml RTU

Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Zelluläre Lokalisation:Nuclear
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human TdT protein
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Kontrolle:Thymus (TdT positive)
Synonyme:TdT, DNA nucleotidylexotransferase, DNTT
Verfügbar in folgenden Ländern:world wide

TdT is a specialized DNA polymerase that adds N-nucleotides to the V, D, and J exons during antibody gene recombination enabling junctional diversity. It is expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells, it is not expressed in pre-B-Cell ALL and normal mature T-or B-lymphocytes. This antibody detects normal cortical thymocytes and primitive lymphocytes; it detects an enzyme found in the nucleus of normal hematopoietic cells, normal cortical thymocytes and in the cytoplasm of megakaryocytes of the bone marrow. Anti-TdT is positive for approximately one third of all cases of chronic myeloid leukemia, making it a good indicator of better response to chemotherapy.