Tenascin C belongs to the tenascin family of extracellular matrixproteins. It is widely expressed during embryogenesis. In the embryo it is made by migrating cells like the neural crest; it is also abundant in developing tendons, bone and cartilage. This antibody recognizes the 210 kDa glycoprotein Tenascin C in both normal and hyperproliferative/neoplastic tissues. In adults, it is increased in hyperproliferative diseases and in stroma of neoplasms, such as glioma and carcinomas of breast, lung and squamous epithelia.