TdT

Rb

Artikelnummer:TE027-H
Menge:
Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human TdT protein
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Kontrolle:Thymus (TdT positive)
Synonyme:TdT, DNA nucleotidylexotransferase, DNTT, Terminal deoxynucleotidyltransferase
Verfügbar in folgenden Ländern:worldwide
Beschreibung

TdT is a specialized DNA polymerase that adds N-nucleotides to the V, D, and J exons during antibody gene recombination enabling junctional diversity. It is expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells, it is not expressed in pre-B-Cell ALL and normal mature T-or B-lymphocytes. This antibody detects normal cortical thymocytes and primitive lymphocytes; it detects an enzyme found in the nucleus of normal hematopoietic cells, normal cortical thymocytes and in the cytoplasm of megakaryocytes of the bone marrow. Anti-TdT is positive for approximately one third of all cases of chronic myeloid leukemia, making it a good indicator of better response to chemotherapy.

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