Synaptophysin

Rb, 0.5 ml Conc.

Artikelnummer:1-SY028-05
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Kontrolle:Pancreatic islet cells
Zelluläre Lokalisation:Cytoplasmic
Fixierung:1) NOTOXhisto 2) Formalin
Anwendung AK:IHC(p),IHC(f)
Immunogen:Synaptophysin
Ig Unterklasse:IgG
Spezies:Rabbit
Klon:Polyclonal
Format AK:Concentrate
Reaktivität AK:Human, others not tested.
Synonyme:Major synaptic vesicle protein p38, SYP, MRXSYP
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Synaptophysin is a synaptic vesicle glycoprotein that is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. This antibody is a marker for neuroendocrine tumors, and its ubiquity at the synapse has led to the use of synaptophysin immunostaining for quantification of synapses. This antibody reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas and gastrointestinal mucosa; with neurons of the brain, spinal cord, retina, and with Paneth's cells in the gastrointestinal tract and gastric parietal cells. The expression of synaptophysin is independent of the presence of NSE or other neuroendocrine markers; it is an independent broad-range marker of neural and neuroendocrine differentiation.

Literatur

[1] Kwon SE and Chapman ER (2011) Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons. Neuron. 70(5):847-54.
[2] Gould VE, Wiedenmann B, Lee I, et al. (1987) Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry. Am J Pathol. 126(2): 243-257.

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