Signal transducer and activator of transduction 6/STAT6

Rb, 1 ml RTU

Artikelnummer:2-SI019-07
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human STAT6
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic, nuclear
Kontrolle:Human skin carcinoma tissue, solitary fibrous tumor
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:signal transducers and activators of transduction 6, D12S1644, IL 4 STAT, IL4 STAT, Interleukin 4 Induced, Interleukin 4 Induced Transcription Factor IL4 STAT, Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced, Signal Transducer And Activator Of Transcription 6 Nirs Variant 1, STAT 6, STAT interleukin4 induced, STAT6B, STAT6C, Transcription factor IL 4 STAT.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

STAT6 is a transcription factor that carries out a dual function: signal transduction and activation of transcription. It is involved in interleukin-4 signalling.

Literatur

[1] Shahmarvand N, Nagy A, Shahryari J and Ohgami RS (2018): Mutations in the signal transducer and activator of transcription family of genes in cancer. Cancer Sci. 109(4):926-933.
[2] Szebeni GJ, Vizler C, Kitajka K and Puskas LG (2017): Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters. Mediators Inflamm. 2017:9294018.
[3] Cheah AL, Billings SD, Goldblum JR et al. (2014): STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics. Pathology. 46(5):389-95.
[4] Schweizer L, Koelsche C, Sahm F et al. (2013): Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. Acta Neuropathol. 125(5):651-8.
[5] Koelsche C, Schweizer L, Renner M et al. (2014): Nuclear relocation of STAT6 reliably predicts NAB2- STAT6 fusion for the diagnosis of solitary fibrous tumour. Histopathology. 65(5):613-22.
[6] Fenghao X, Saxon A, Nguyen AJ et al. (1995): Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon-gamma activation site-like sequence upstream of the I epsilon exon in a human B cell line. Evidence for the involvement of Janus kinase 3 and interleukin-4 Stat. Clin Invest. 96(2):907-14.

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