STAT6

Rb

Artikelnummer:SI019-H
Menge:
Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human STAT6
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Cytoplasmic, nuclear
Kontrolle:Skin carcinoma, solitary fibrous tumor
Synonyme:signal transducers and activators of transduction 6, D12S1644, IL 4 STAT, IL4 STAT, Interleukin 4 Induced, Interleukin 4 Induced Transcription Factor IL4 STAT, Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced, Signal Transducer And Activator Of Transcription 6 Nirs Variant 1, STAT 6, STAT interleukin4 induced, STAT6B, STAT6C, Transcription factor IL 4 STAT.
Verfügbar in folgenden Ländern:worldwide
Beschreibung

STAT family consists of seven genes, STAT1 to STAT4, STAT5A, STAT5B and STAT6, that are involved in regulating cellular proliferation, apoptosis, angiogenesis and the immune system response. STAT6 is a transcription factor that carries out a dual function: signal transduction and activation of transcription. It is involved in interleukin-4 signalling and seems to play an important role in cancer. STAT6 has been found to form recurrent fusions with NAB2 on chromosome 12q13 in the majority of solitary fibrous tumors (SFTs) excluding meningiomas, hemangioblastomas, schwannomas, and hemangiomas. The fusion enables cytosolic STAT6 to migrate to the nucleus. The detection of nuclear relocation of STAT6 with immunohistochemistry is a characteristic of SFTs, and may serve as a diagnostic marker that indicates NAB2-STAT6 fusion.

Literatur

[1] Shahmarvand N, Nagy A, Shahryari J and Ohgami RS (2018): Mutations in the signal transducer and activator of transcription family of genes in cancer. Cancer Sci. 109(4):926-933.
[2] Szebeni GJ, Vizler C, Kitajka K and Puskas LG (2017): Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters. Mediators Inflamm. 2017:9294018.
[3] Cheah AL, Billings SD, Goldblum JR et al. (2014): STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics. Pathology. 46(5):389-95.
[4] Schweizer L, Koelsche C, Sahm F et al. (2013): Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. Acta Neuropathol. 125(5):651-8.
[5] Koelsche C, Schweizer L, Renner M et al. (2014): Nuclear relocation of STAT6 reliably predicts NAB2-STAT6 fusion for the diagnosis of solitary fibrous tumour. Histopathology. 65(5):613-22.
[6] Fenghao X, Saxon A, Nguyen AJ et al. (1995): Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon-gamma activation site-like sequence upstream of the I epsilon exon in a human B cell line. Evidence for the involvement of Janus kinase 3 and interleukin-4 Stat. Clin Invest. 96(2):907-14.

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