SOX2

Rb, 0.5 ml Conc.

Artikelnummer:1-SO108-05
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human Sox2
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Nuclear
Kontrolle:Fetal brain, glioma
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:transcriptional factor SOX2, ANOP3, cb236, Delta EF2a, lcc, MCOPS3, MGC148683, MGC2413, RGD1565646, Sex determining region Y box 2, Sex determining region Y-box 2, SOX 2, SRY (sex determining region Y) box 2, SRY box containing gene 2, SRY related HMG box 2, SRY related HMG box gene 2, SRY-box 2, ysb.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

SOX2 is a transcription factor involved in the regulation of embryonic development and in the determination of cell fate. It is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is expressed in fetal brain and is a marker for multipotential neural stem cells. In tumors, SOX2 expression is observed in teratoma of the central nervous system, melanoma, testicular germ cell tumor, cervical carcinoma, lung cancer, breast cancer with basal cell phenotype, and squamous cell carcinoma of the gastrointestinal tract.

Literatur

[1] Phi JH, Park SH, Paek SH et al. (2007): Expression of Sox2 in mature and immature teratomas of central nervous system. Mod Pathol. 20(7):742-8.
[2] Sholl LM, Barletta JA, Yeap BY et al. (2010): Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma. Am J Surg Pathol. 34(8):1193-8.
[3] Laga AC, Lai CY, Zhan Q et al. (2010): Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology. Am J Pathol. 176(2):903-13.
[4] Nonaka D (2009): Differential expression of SOX2 and SOX17 in testicular germ cell tumors. Am J Clin Pathol. 131(5):731-6.
[5] Rodriguez-Pinilla SM, Sarrio D, Moreno-Bueno G et al. (2007): Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer. Mod Pathol. 20(4):474-81.
[6] Uwanogho D, Rex M, Cartwright EJ et al. (1995): Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development. Mech Dev. 49(1-2):23-36.

Kontakt