SOX2

Rb

Artikelnummer:SO108-H_RUO
Menge:
Technische Daten
Change(s) made:Complete revision
Status:Research Use Only (RUO)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human Sox2
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Zelluläre Lokalisation:Nuclear
Kontrolle:Fetal brain, glioma
Synonyme:transcriptional factor SOX2, ANOP3, cb236, Delta EF2a, lcc, MCOPS3, MGC148683, MGC2413, RGD1565646, Sex determining region Y box 2, Sex determining region Y-box 2, SOX 2, SRY (sex determining region Y) box 2, SRY box containing gene 2, SRY related HMG box 2, SRY related HMG box gene 2, SRY-box 2, ysb.
Verfügbar in folgenden Ländern:worldwide
Beschreibung

SOX2 is a transcription factor involved in the regulation of embryonic and cell development, is required for the maintenance of stem cells in the central nervous system and also regulates gene expression in the stomach. SOX2 is expressed in the fetal brain and is a marker for multipotent neural stem cells. In tumors, SOX2 expression is observed in central nervous system teratomas, melanoma, testicular germ cell tumors, cervical cancer, lung cancer, basal cell phenotype breast cancer, and squamous cell carcinoma of the gastrointestinal tract.

Literatur

[1] Phi JH, Park SH, Paek SH et al. (2007): Expression of Sox2 in mature and immature teratomas of central nervous system. Mod Pathol. 20(7):742-8.
[2] Sholl LM, Barletta JA, Yeap BY et al. (2010): Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma. Am J Surg Pathol. 34(8):1193-8.
[3] Laga AC, Lai CY, Zhan Q et al. (2010): Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology. Am J Pathol. 176(2):903-13.
[4] Nonaka D (2009): Differential expression of SOX2 and SOX17 in testicular germ cell tumors. Am J Clin Pathol. 131(5):731-6.
[5] Rodriguez-Pinilla SM, Sarrio D, Moreno-Bueno G et al. (2007): Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer. Mod Pathol. 20(4):474-81.
[6] Uwanogho D, Rex M, Cartwright EJ et al. (1995): Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development. Mech Dev. 49(1-2):23-36.

Kontakt