S100

4C4.9, Ms, 7 ml RTU

Artikelnummer:2-S1001-13
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Zelluläre Lokalisation:Cytoplasmic
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:4C4.9
Spezies:Mouse
Ig Unterklasse:IgG2a
Immunogen:S100 Protein
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Kontrolle:Melanoma
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

S-100 protein is a family of low molecular weight protein characterized by two calcium binding sites of the helix-loop-helix ("EF-hand type") conformation. There are at least 21 different types of S100 proteins. This antibody is specific for beta subunit of S-100 protein. S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chrondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells. This antibody detects neoplasms derived from these cells, a large number of tumors of the salivary gland, adipose and cartilaginous tissue, Schwann cell derived tumors, and almost all malignant melanomas and cases of histiocytosis x. Despite the fact that S-100 protein is an ubiquitous substance, its demonstration is of great value in the identification of several neoplasms, particularly melanomas.

Literatur

[1] Donato R (1999): Functional roles of S100 betas, calcium-binding proteins of the EF-hand type. Biochim Biophys Acta. 1450(3):191-231.
[2] Clarkson KS, Sturdgess IC and Molyneux AJ (2001): The usefulness of tyrosinase in the immunohistochemical assessment of melanocytic lesions: a comparison of the novel T311 antibody (anti-tyrosinase) with S-100, HMB45, and A103 (anti-melan-A). J Clin Pathol. 54(3):196-200.
[3] Smith SP and Shaw GS (1998): A novel calciumsensitive switch revealed by the structure of human S100B in the calcium-bound form. Structure. 6(2):211-22.
[4] HydŽn H, Lange PW (1970): S100 brain protein: correlation with behavior. Proc Natl Acad Sci U S A. 67(4):1959-66.

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