S100 protein

Rb, 1 ml RTU

Artikelnummer:2-S1003-07
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human S100 beta protein
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Skin, melanoma
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Reacts strongly with S100B. S100 Beta is a member of the S100 family of proteins and is involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. The protein is expressed in glial cells of the central and peripheral nervous system, chondrocytes, adipocytes and melanocytes. The antibody S100 Beta is a useful marker for diagnosis of melanoma and tumors of
nerves system.

Literatur

[1] Donato R (1999): Functional roles of S100 betas, calcium-binding proteins of the EF-hand type. Biochim Biophys Acta. 1450(3):191-231.
[2] Clarkson KS, Sturdgess IC and Molyneux AJ (2001): The usefulness of tyrosinase in the immunohistochemical assessment of melanocytic lesions: a comparison of the novel T311 antibody (anti-tyrosinase) with S-100, HMB45, and A103 (anti-melan-A). J Clin Pathol. 54(3):196-200.
[3] Smith SP and Shaw GS (1998): A novel calciumsensitive switch revealed by the structure of human S100B in the calcium-bound form. Structure. 6(2):211-22.
[4] HydŽn H, Lange PW (1970): S100 brain protein: correlation with behavior. Proc Natl Acad Sci U S A. 67(4):1959-66.

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