Protein gene product 9.5
Rb, 0.5 ml Conc.
Technische Daten
Reaktivität AK: | Human, others not tested. | Format AK: | Concentrate | Klon: | Polyclonal | Spezies: | Rabbit | Immunogen: | Protein gene product 9.5 | Anwendung AK: | IHC(p),IHC(f) | Fixierung: | 1) NOTOXhisto 2) Formalin | Zelluläre Lokalisation: | Cytoplasmic | Kontrolle: | Nerve tissue, bowel wall | Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | Synonyme: | PGP 9.5, Ubiquitin carboxyl-terminal hydrolase-1, UCH-L1, PARK5 | Verfügbar in folgenden Ländern: | world wide (except US) | Status: | IVD |
Beschreibung
PGP9.5/Ubiquitin carboxy-terminal hydrolase L1 is a deubiquitinating enzyme that hydrolyzes small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. It is expressed in neurons, in cells of the diffuse neuroendocrine system and their tumors; it has been subsequently documented in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts.
Literatur
[1] Campbell LK, Thomas JR, Lamps LW et al. (2003):
Protein gene product 9.5 (PGP 9.5) is not a specific
marker of neural and nerve sheath tumors: an
immunohistochemical study of 95 mesenchymal
neoplasms. Mod Pathol. 16(10):963-9.
[2] Doran JF, Jackson P, Kynoch PA and Thompson RJ
(1983): Isolation of PGP 9.5, a new human neuronespecific
protein detected by high-resolution twodimensional
electrophoresis. J Neurochem. 40(6):1542-7.
[3] Thompson RJ, Doran JF, Jackson P et al. (1983):
PGP 9.5--a new marker for vertebrate neurons and
neuroendocrine cells. Brain Res. 278(1-2):224-8.
[4] Day IN and Thompson RJ (1987): Molecular cloning of
cDNA coding for human PGP 9.5 protein. A novel
cytoplasmic marker for neurones and neuroendocrine
cells. FEBS Lett. 210(2):157-60.
[5] Wilson PO, Barber PC, Hamid QA et al. (1988): The
immunolocalization of protein gene product 9.5 using
rabbit polyclonal and mouse monoclonal antibodies. Br J
Exp Pathol. 69(1):91-104.
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