Protein gene product 9.5

Rb, 0.5 ml Conc.

Artikelnummer:1-PR153-05
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:Polyclonal
Spezies:Rabbit
Immunogen:Protein gene product 9.5
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Nerve tissue, bowel wall
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:PGP 9.5, Ubiquitin carboxyl-terminal hydrolase-1, UCH-L1, PARK5
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

PGP9.5/Ubiquitin carboxy-terminal hydrolase L1 is a deubiquitinating enzyme that hydrolyzes small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. It is expressed in neurons, in cells of the diffuse neuroendocrine system and their tumors; it has been subsequently documented in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts.

Literatur

[1] Campbell LK, Thomas JR, Lamps LW et al. (2003): Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms. Mod Pathol. 16(10):963-9.
[2] Doran JF, Jackson P, Kynoch PA and Thompson RJ (1983): Isolation of PGP 9.5, a new human neuronespecific protein detected by high-resolution twodimensional electrophoresis. J Neurochem. 40(6):1542-7.
[3] Thompson RJ, Doran JF, Jackson P et al. (1983): PGP 9.5--a new marker for vertebrate neurons and neuroendocrine cells. Brain Res. 278(1-2):224-8.
[4] Day IN and Thompson RJ (1987): Molecular cloning of cDNA coding for human PGP 9.5 protein. A novel cytoplasmic marker for neurones and neuroendocrine cells. FEBS Lett. 210(2):157-60.
[5] Wilson PO, Barber PC, Hamid QA et al. (1988): The immunolocalization of protein gene product 9.5 using rabbit polyclonal and mouse monoclonal antibodies. Br J Exp Pathol. 69(1):91-104.

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