Programmed Death 1

QR2, Rb, 1 ml RTU

Artikelnummer:2-PR294-07
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Kontrolle:Tonsil, Renal cell carcinoma
Zelluläre Lokalisation:Cytoplasmic, membranous
Fixierung:1) NOTOXhisto 2) Formalin
Immunogen:Synthetic peptide of the PD-1 protein
Ig Unterklasse:IgG1
Spezies:Rabbit
Klon:QR2
Format AK:Ready-to-use
Reaktivität AK:Human, others not tested
Anwendung AK:IHC(p),IHC(f)
Synonyme:PD-1, CD279
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Programmed death-1 (PD-1), also known as CD279, is a receptor for PDL1 and PDL2. PD1 plays a crucial role in regulating peripheral tolerance and tumor immunity. Increased expression of PD-1 has been reported to be associated with poor prognosis in hepatocellular carcinoma (HCC) and renal cell carcinoma. PD-1 is a useful marker for angioimmunoblastic lymphoma.

Literatur

[1] Dorfman DM, Brown JA, Shahsafaei A, & Freeman GJ (2006). Programmed Death-1 (PD-1) is a Marker of Germinal Center- associated T Cells and Angioimmunoblastic T-Cell Lymphoma. Am J Surg Pathol. 30: 802-10.
[2] Ostrand-Rosenberg S, Horn LA, & Haile ST (2014). The Programmed Death-1 Immune Suppressive Pathway: Barrier to Anti-Tumor Immunity. J Immunol. 193(8): 3835-41.
[3] Kantekure K, Yang Y, Raghunath P, et al. (2012): Expression patterns of the immunosuppressive proteins PD-1/CD279 and PD-L1/CD274 at different stages of cutaneous T-cell lymphoma (CTCL)/mycosis fungoides (MF). Am J Dermatopathol. 34: 126-8.
[4] Zeng Z, Shi F, Zhou L, et al. (2011): Expression patterns of the immunosuppressive proteins PD-1/ CD279 and PD-L1/CD274 at different stages of cutaneous T-cell lymphoma (CTCL)/mycosis fungoides (MF). PLoS One. 6(9): e23621.
[5] Thompson RH, Dong H, Lohse CM, et al. (2007): PD-1 Is Expressed by Tumor-Infiltrating Immune Cells and Is Associated with Poor Outcome for Patients with Renal Cell Carcinoma. Clin Cancer Res. 13: 1757-61.
[6] Muenst S, Soysal SD, Gao F, et al. (2013): The presence of programmed death 1 (PD-1)-positive tumorinfiltrating lymphocytes is associated with poor prognosis in human breast cancer. Breast Cancer Res Treat. 139(3): 667-76.
[7] Konishi J, Yamazaki K, Azuma M, et al. (2004): B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression. Clin Cancer Res. 10: 5094-100.
[8] DÕIncecco A, Andreozzi M, Ludovini V, et al. (2015): PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients. Br J Cancer. 112(1): 95-102.
[9] Ishida Y, Agata Y, Shibahara K and Honjo T (1992): Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11(11):3887-95.

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