Technische Daten
Beschreibung
Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. The role of perforin-mediated cytotoxicity has been demonstrated in various autoimmune diseases. In addition, it seems that T-cell cytotoxicity against keratinocytes is mediated by perforin in some inflammatory skin diseases.
Literatur
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