Perforin

Ms, 3 ml RTU

Artikelnummer:2-PE058-10
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Spezies:Mouse
Ig Unterklasse:IgG1
Immunogen:Perforin
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Perinuclear cytoplasmic
Kontrolle:Spleen
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. The role of perforin-mediated cytotoxicity has been demonstrated in various autoimmune diseases. In addition, it seems that T-cell cytotoxicity against keratinocytes is mediated by perforin in some inflammatory skin diseases.

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