Paxillin

Rb

Artikelnummer:PA081-H_RUO
Menge:
Technische Daten
Change(s) made:Complete revision
Status:Research Use Only (RUO)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human Paxillin
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Tonsil
Synonyme:Paired box protein Pax 1, PAX 1, PAX1, Paxillin alpha, PXN, PXN protein, FLJ16691, FLJ23042, FLJ16691, PAXI_HUMAN, Paxillin, PXN protein.
Verfügbar in folgenden Ländern:worldwide
Beschreibung

Paxillin is a signal transduction adaptor protein that is expressed at focal adhesions of non-striated cells and at costameres of striated muscle cells. It functions to adhere cells to the extracellular matrix. Mutations as well as abnormal expression of paxillin protein has been implicated in the progression of various cancers. Enhanced expression of paxillin has been detected in premalignant areas of hyperplasia, squamous metaplasia and goblet cell metaplasia, as well as dysplastic lesions and carcinoma in high-risk patients with lung adenocarcinoma. Mutations have been associated with enhanced tumor growth, cell proliferation, and invasion in lung cancer tissues.

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