Technische Daten
Beschreibung
PU.1 is a transcription factor that activates gene expression during myeloid and B-lymphoid cell development. It is a key molecule of hematopoiesis. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of Ôdifferentiation therapyÍ to restore normal cellular differentiation of leukemic cells is discussed.
Literatur
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