PU.1

Rb

Artikelnummer:PU031-H_RUO
Menge:
Technische Daten
Change(s) made:Complete revision
Status:Research Use Only (RUO)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human transcription factor PU.1 protein
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Zelluläre Lokalisation:Nuclear
Kontrolle:Tonsil, lymphoma
Synonyme:SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene
Verfügbar in folgenden Ländern:worldwide
Beschreibung

PU.1 is a transcription factor that activates gene expression during myeloid and B-lymphoid cell development. It is a key molecule of hematopoiesis. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of Ôdifferentiation therapyÍ to restore normal cellular differentiation of leukemic cells is discussed.

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