PAX5

Rb, 1 ml RTU

Artikelnummer:2-PA075-07
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human PAX5
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Nuclear
Kontrolle:Tonsil, B lymphoblastic neoplasms
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:PAX5 expression is not only continuously required for B cell lineage commitment during early B cell development but also for B lineage maintenance. PAX5 is found in most cases of mature and precursor B cell non-Hodgkin lymphomas/leukemias. Pax-5 is not detected in Multiple myeloma and solitary plasmacytoma cell lymphomas do express Pax5 except for those with terminal B cell differentiation. T cell neoplasms do not stain with anti-Pax5, however there is a strong association with CD20 expression.
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

PAX5 is a transcription factor and important regulator in early development. Alterations in the expression of PAX5 gene are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis.

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