Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human PAX5
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Zelluläre Lokalisation:Nuclear
Kontrolle:Tonsil, B lymphoblastic neoplasms
Synonyme:PAX5 expression is not only continuously required for B cell lineage commitment during early B cell development but also for B lineage maintenance. PAX5 is found in most cases of mature and precursor B cell non-Hodgkin lymphomas/leukemias. Pax-5 is not detected in Multiple myeloma and solitary plasmacytoma cell lymphomas do express Pax5 except for those with terminal B cell differentiation. T cell neoplasms do not stain with anti-Pax5, however there is a strong association with CD20 expression.
Verfügbar in folgenden Ländern:worldwide

PAX5 is a transcription factor and important regulator in early development. Alterations in the expression of PAX5 gene are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis.