Technische Daten
Change(s) made:Complete revision
Status:Research Use Only (RUO)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human OCT2
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Zelluläre Lokalisation:Nucelar, cytoplasmic may be observed
Kontrolle:Tonsil, lymphoma
Synonyme:organic cation transporter OCT2, POU domain, class 2, transcription factor 2, Octamer-binding transcription factor 2, Oct-2, OTF-2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, POU2F2, NF A2, Oct 2, Octamer binding transcription factor 2
Verfügbar in folgenden Ländern:worldwide

Oct-2 is a octamer transcription factor which is part of the POU family regulating B-cell-specific genes. The level of its expression can be used as a marker of B-cell lineage and differentiation. High expression is found in germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells. Various lymphomas are also positive for this marker including the following: B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, classic Hodgkin lymphoma.