Technische Daten
Reaktivität AK: | Human, others not tested. | Format AK: | Ready-to-use | Klon: | Polyclonal | Spezies: | Rabbit | Ig Unterklasse: | IgG | Immunogen: | Napsin A | Anwendung AK: | IHC(p),IHC(f) | Fixierung: | 1) NOTOXhisto 2) Formalin | Zelluläre Lokalisation: | Cytoplasmic | Kontrolle: | Lung adenocarcinoma, kidney | Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | Synonyme: | ASP 4, ASP4, ASP-4,Aspartyl protease 4, KAP, Kdap, NAP1, NAPA, NAPSA_HUMAN, Napsin 1, napsin A aspartic peptidase, Napsin A precursor, Napsin-1, Napsin-A, Pronapsin A, SNAPA, TA01/TA02. | Verfügbar in folgenden Ländern: | world wide (except US) | Status: | IVD |
Beschreibung
Napsin is a pepsin-like aspartic protease with a molecular weight of approximately 38 kDa. Napsin A is closely related to Napsin B. Napsin A is expressed as a single chain protein in type II pneumocytes and in adenocarcinomas of the lung and kidney. The high specificity expression of Napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of unknown orgin. Therefore Napsin A is a promising marker for the diagnosis of primary lung adenocarcinoma.
Literatur
[1] Ueno T, Linder S and Elmberger G (2003): Aspartic
proteinase napsin is a useful marker for diagnosis of
primary lung adenocarcinoma. Br J Cancer. 88(8):1229-
33.
[2] Brasch F, Ochs M, Kahne T et al. (2003): Involvement
of napsin A in the C- and N-terminal processing of
surfactant protein B in type-II pneumocytes of the human
lung. J Biol Chem. 278(49):49006-14.
[3] Hirano T, Auer G, Maeda M et al. (2000): Human
tissue distribution of TA02, which is homologous with a
new type of aspartic proteinase, napsin A. Jpn J Cancer
Res. 91(10):1015-21.
[4] Tatnell PJ, Powell DJ, Hill J et al. (1998): Napsins:
new human aspartic proteinases. Distinction between two
closely related genes. FEBS Lett. 441(1):43-8.
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