Napsin A

Rb, 1 ml RTU

Artikelnummer:2-NA036-07
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Napsin A
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Lung adenocarcinoma, kidney
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:ASP 4, ASP4, ASP-4,Aspartyl protease 4, KAP, Kdap, NAP1, NAPA, NAPSA_HUMAN, Napsin 1, napsin A aspartic peptidase, Napsin A precursor, Napsin-1, Napsin-A, Pronapsin A, SNAPA, TA01/TA02.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Napsin is a pepsin-like aspartic protease with a molecular weight of approximately 38 kDa. Napsin A is closely related to Napsin B. Napsin A is expressed as a single chain protein in type II pneumocytes and in adenocarcinomas of the lung and kidney. The high specificity expression of Napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of unknown orgin. Therefore Napsin A is a promising marker for the diagnosis of primary lung adenocarcinoma.

Literatur

[1] Ueno T, Linder S and Elmberger G (2003): Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma. Br J Cancer. 88(8):1229- 33.
[2] Brasch F, Ochs M, Kahne T et al. (2003): Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. J Biol Chem. 278(49):49006-14.
[3] Hirano T, Auer G, Maeda M et al. (2000): Human tissue distribution of TA02, which is homologous with a new type of aspartic proteinase, napsin A. Jpn J Cancer Res. 91(10):1015-21.
[4] Tatnell PJ, Powell DJ, Hill J et al. (1998): Napsins: new human aspartic proteinases. Distinction between two closely related genes. FEBS Lett. 441(1):43-8.

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