Neuron Specific Enolase represents one of the three main groups of enolases, the two remaining enolases are non-neuronal and muscle-specific enolases. NSE is present in high concentration in neurons and in central and peripheral neuroendocrine cells. The antibody reacts with cells of neural and neuroendocrine lineage. It can be used for identification of peripheral nerves, neural and neuroendocrine tumors, such as neuroblastomas, retinoblastomas, desmoplastic malignant melanoma, small-cell lung cancer. Detection of neural and neuroendocrine tumors requires addtional markers such as chromogranin, synaptophysin and keratins in that specific panel.