Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human NKX3.1
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Kontrolle:Normal prostate, prostate cancer
Synonyme:anti BAPX 2 antibody, anti BAPX2 antibody, anti Homeobox protein NK-3 homolog A antibody, anti Homeobox protein Nkx 3 1 antibody, anti Homeobox protein Nkx-3 1 antibody, anti Homeobox protein Nkx3 1 antibody, anti NK homeobox (Drosophila) family 3 A antibody, anti NK homeobox family 3 A antibody, anti NK homeobox, family 3, member A antibody, anti NK3 homeobox 1 antibody, anti NK3 transcription factor homolog A antibody, anti NK3 transcription factor related locus 1 antibody, anti NKX 3 antibody, anti Nkx 3 1 antibody, anti NKX 3A antibody, anti NKX3 1 antibody, anti NKX3 antibody, anti Nkx3-1 antibody, anti NKX3 1 antibody, anti Nkx3 1, mouse, homolog of antibody, anti NKX31_HUMAN antibody, anti NKX3A antibody
Verfügbar in folgenden Ländern:worldwide

NKX3.1 is a transcription factor that acts as a putative prostate tumor suppressor. It is largely expressed in a prostate and androgen-regulated manner. NKX3.1 is expressed in normal prostate epithelium. Loss of the protein is a common finding in human prostate cancer and intraepithelial prostate neoplasia. The antibody NKX3.1 is a highly sensitive and specific marker for prostate adenocarcinoma and is useful in a panel with other prostate markers such as PSA, PSAP or Prostein, particularly in the case of low-differentiation tumors in which PSA, PSAP and / or Prostein are poorly expressed or can be lost. Primary and metastatic prostate carcinoma show a lower NKX3.1 staining intensity than the normal prostate.


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