NKX3.1

Rb

Artikelnummer:NK001-H
Menge:
Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human NKX3.1
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Kontrolle:Normal prostate, prostate cancer
Synonyme:anti BAPX 2 antibody, anti BAPX2 antibody, anti Homeobox protein NK-3 homolog A antibody, anti Homeobox protein Nkx 3 1 antibody, anti Homeobox protein Nkx-3 1 antibody, anti Homeobox protein Nkx3 1 antibody, anti NK homeobox (Drosophila) family 3 A antibody, anti NK homeobox family 3 A antibody, anti NK homeobox, family 3, member A antibody, anti NK3 homeobox 1 antibody, anti NK3 transcription factor homolog A antibody, anti NK3 transcription factor related locus 1 antibody, anti NKX 3 antibody, anti Nkx 3 1 antibody, anti NKX 3A antibody, anti NKX3 1 antibody, anti NKX3 antibody, anti Nkx3-1 antibody, anti NKX3 1 antibody, anti Nkx3 1, mouse, homolog of antibody, anti NKX31_HUMAN antibody, anti NKX3A antibody
Verfügbar in folgenden Ländern:worldwide
Beschreibung

NKX3.1 is a transcription factor that acts as a putative prostate tumor suppressor. It is largely expressed in a prostate and androgen-regulated manner. NKX3.1 is expressed in normal prostate epithelium. Loss of the protein is a common finding in human prostate cancer and intraepithelial prostate neoplasia. The antibody NKX3.1 is a highly sensitive and specific marker for prostate adenocarcinoma and is useful in a panel with other prostate markers such as PSA, PSAP or Prostein, particularly in the case of low-differentiation tumors in which PSA, PSAP and / or Prostein are poorly expressed or can be lost. Primary and metastatic prostate carcinoma show a lower NKX3.1 staining intensity than the normal prostate.

Literatur

[1] Gurel B, Ali TZ, Montgomery EA et al. (2010): NKX3.1 as a marker of prostatic origin in metastatic tumors. Am J Surg Pathol. 34(8):1097-105.
[2] Abate-Shen C, Shen MM and Gelmann E (2008): Integrating differentiation and cancer: the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis. Differentiation. 76(6):717-27.
[3] Bhatia-Gaur R, Donjacour AA, Sciavolino PJ et al. (1999): Roles for Nkx3.1 in prostate development and cancer. Genes Dev. 13(8):966-77.
[4] Bieberich CJ, Fujita K, He WW and Jay G (1996): Prostate-specific and androgen-dependent expression of a novel homeobox gene. J Biol Chem. 271(50):31779-82.

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