Technische Daten
Change(s) made:Complete revision
Status:Research Use Only (RUO)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human NDRG1
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Zelluläre Lokalisation:Cytoplasmic, membranous, nuclear
Kontrolle:Prostate hyperplasia
Synonyme:N-myc downstream regulated gene 1, TDD5, 42 kDa, cap43, cmt4d, Differentiation related gene1 protein, Drg 1, drg1, gc4, hmsnl, Human mRNA for RTP complete cds, N myc downstream regulated gene 1 protein, Ndr 1, NDRG 1, Nickel specific induction protein Cap43, Nmyc downstream regulated gene1, Protein NDRG1, Protein regulated by oxygen 1 , Protein regulated by oxygen1, proxy1, reducin, Reducing agents and tunicamycin responsive protein, rit42, rtp, targ1, tdds, tunicamycin-responsive protein.
Verfügbar in folgenden Ländern:worldwide

NDRG1 is involved in embryogenesis and development, cell growth and differentiation, lipid biosynthesis and myelination, stress responses, immunity, DNA repair and cell adhesion among other functions. NDRG1 is localised in the cytoplasm, nucleus and mitochondrion, at probabilities of 47.8 %, 26.1 % and 8.7 %, respectively. In response to DNA damage NDRG1 translocates from the cytoplasm to the nucleus, where it may inhibit cell growth and promote DNA repair mechanisms. NDRG1 is a potent, iron-regulated growth and metastasis suppressor that was found to be negatively correlated with cancer progression in a number of tumors, including prostate, pancreatic, breast, and colon cancers. NDRG1 has marked anti-oncogenic activity, being associated with decreased cell proliferation, migration, invasion, and angiogenesis.