Mouse double minute 2/MDM2

SMP14, Ms, 1 ml Conc.

Artikelnummer:1-MO029-07
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:SMP14
Spezies:Mouse
Ig Unterklasse:IgG2a
Immunogen:Synthetic peptide of human MDM2
Anwendung AK:IHC(p),IHC(f),WB,ELISA
Fixierung:1) NOTOXhisto 2) Formalin
Kontrolle:More than 50% of soft tissue sarcomas are positive for MDM2, breast carcinoma
Lagerung AK:Aliquot and store at - 20 °C. Do not use after expiration date indicated on the vial.
Synonyme:Double minute 2 protein, Hdm 2, HDM2, MDM 2, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa, MDM2BP, Mouse Double Minute 2, MTBP, Murine Double Minute Chromosome 2, Oncoprotein Mdm2, p53 Binding Protein Mdm2, Ubiquitin protein ligase E3 Mdm2.
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

Recognizes a protein of 90 kDa which is identified as the human homolog of murine double minute-2 (MDM2). MDM2 is overexpressed in many tumors. Its principal function is the ubiquitination and degradation of p53 tumour suppressor protein. SMP14 also cross reacts with some cytokeratins (6, 14 & 16) which may be a problem when working with certain epithelial cells and not fibroblasts.

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