Mouse double minute 2/MDM2
SMP14, Ms, 1 ml Conc.
Technische Daten
Reaktivität AK: | Human, others not tested. | Format AK: | Concentrate | Klon: | SMP14 | Spezies: | Mouse | Ig Unterklasse: | IgG2a | Immunogen: | Synthetic peptide of human MDM2 | Anwendung AK: | IHC(p),IHC(f),WB,ELISA | Fixierung: | 1) NOTOXhisto 2) Formalin | Kontrolle: | More than 50% of soft tissue sarcomas are positive for MDM2, breast carcinoma | Lagerung AK: | Aliquot and store at - 20 °C. Do not use after expiration date indicated on the vial. | Synonyme: | Double minute 2 protein, Hdm 2, HDM2, MDM 2, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa, MDM2BP, Mouse Double Minute 2, MTBP, Murine Double Minute Chromosome 2, Oncoprotein Mdm2, p53 Binding Protein Mdm2, Ubiquitin protein ligase E3 Mdm2. | Verfügbar in folgenden Ländern: | world wide | Status: | RUO |
Beschreibung
Recognizes a protein of 90 kDa which is identified as the human homolog of murine double minute-2 (MDM2). MDM2 is overexpressed in many tumors. Its principal function is the ubiquitination and degradation of p53 tumour suppressor protein. SMP14 also cross reacts with some cytokeratins (6, 14 & 16) which may be a problem when working with certain epithelial cells and not fibroblasts.
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