Matrix metalloproteinase 7/MMP7

Rb, 7 ml RTU

Artikelnummer:2-MA095-13
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Zelluläre Lokalisation:Cytoplasmic
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human MMP7
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Kontrolle:Tonsil, colon carcinoma
Synonyme:Matrilysin, Matrilysin uterine, Matrin, Matrix Metalloproteinase 7, MMP 7, MMP7, MPSL1, PUMP 1, Pump 1 protease, PUMP1, Uterine Matrilysin, Uterine metalloproteinase.
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

The matrix metalloproteinases (MMPs) are a family of secreted membrane bound zincendopeptidases that can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. MMP7 cleaves a number of substrates including collagen types IV and X, elastin, fibronectin, gelatin, laminin and proteoglycans. Once activated, MMP7 can activate pro-MMP1 and pro-MMP9. MMP7 is widely expressed having been reported in elevated levels in cycling endometrium as well as in colorectal cancers and adenomas, hepatocellular carcinomas, rectal carcinomas, and gliomas.

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