Major vault protein

1014, Ms, 3 ml RTU

Artikelnummer:2-MA043-10
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Zelluläre Lokalisation:Cytoplasmic, nuclear
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:1014
Spezies:Mouse
Ig Unterklasse:IgG1/k
Immunogen:Affinity purified nuclear extract proteins
Anwendung AK:IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Kontrolle:Breast
Synonyme:LRP, Lung Resistance Related Protein, Lung resistance-related protein, Major Vault Protein, MVP, VAULT 1, yVAULT1
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

Major Vault Protein is identical to lung-resistance related protein (LRP) that mediates drug resistance. It is expressed in most normal tissues, in epithelial cells with secretory and excretory functions, in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine; overexpression is found in many multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This antibody is specific for a 104 kDa protein and has shown to interact with the estrogen receptor. Therefore it is especially applicable to study the association of estrogen receptor with vaults as well as the mechanism of estrogenic hormones activity. It is one of four monoclonal antibodies which recognize different epitopes of the protein. This antibody is useful to detect MVP/LRP in a large number of eukaryotic cells including the MCF-7 and Hela tumor cell lines.

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