MSH6

Rb, 1 ml RTU

Artikelnummer:2-MS006-07
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Kontrolle:Colon carcinoma, colon mucosa
Zelluläre Lokalisation:Nuclear
Fixierung:1) NOTOXhisto 2) Formalin
Anwendung AK:IHC(p),IHC(f)
Immunogen:Synthetic peptide of human MSH6
Ig Unterklasse:IgG
Spezies:Rabbit
Klon:Polyclonal
Format AK:Ready-to-use
Reaktivität AK:Human, others not tested.
Synonyme:DNA mismatch repair protein MSH6, G/T mismatch binding protein, GTBP, GTMBP, HNPCC 5, HNPCC5, HSAP, MSH 6, mutS (E. coli) homolog 6, MutS alpha 160 kDa subunit, mutS homolog 6, p160, Sperm associated protein.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

MSH6 is a gene that is involved in DNA mismatch repair. This gene is deficient in many patients with microsatellite instability and it is commonly associated with Hereditary Non-Polyposis Colon Cancer (HNPCC). This antibody is useful in screening patients and families for this condition and is utilized in an IHC panel that includes the antibodies MLH1, MSH2 and PMS2.

Literatur

[1] Edelbrock MA, Kaliyaperumal S and Williams KJ (2013): Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities. Mutat Res. 743-744:53-66.
[2] Vasen HF, Hendriks Y, de Jong AE et al. (2004): Identification of HNPCC by molecular analysis of colorectal and endometrial tumors. Dis Markers. 20(4- 5):207-13.
[3] Kawakami H, Zaanan A and Sinicrope FA (2015): Microsatellite instability testing and its role in the management of colorectal cancer. Curr Treat Options Oncol. 16(7):30.

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