SMP14, Ms

Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG2a
Immunogen:Synthetic peptide of human MDM2
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Zelluläre Lokalisation:Nuclear, cytoplasmic
Kontrolle:More than 50% of soft tissue sarcomas are positive for MDM2, breast carcinoma
Synonyme:Double minute 2 protein, Hdm 2, HDM2, MDM 2, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa, MDM2BP, Mouse Double Minute 2, MTBP, Murine Double Minute Chromosome 2, Oncoprotein Mdm2, p53 Binding Protein Mdm2, Ubiquitin protein ligase E3 Mdm2.
Verfügbar in folgenden Ländern:worldwide

Recognizes a protein of 90 kDa which is identified as the human homolog of murine double minute-2 (MDM2). MDM2 is overexpressed in many tumors. Its principal function is the ubiquitination and degradation of p53 tumour suppressor protein. SMP14 also cross reacts with some cytokeratins (6, 14 & 16) which may be a problem when working with certain epithelial cells and not fibroblasts.