Technische Daten
Status:Research Use Only (RUO)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human MASH1
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Kontrolle:Brain, small cell lung cancer
Change(s) made:Complete revision
Synonyme:Achaete scute complex homolog 1, Achaete scute complex homolog like 1, Achaete scute complex homologue 1, Achaete scute complex homologue like 1, Ascl 1, Ascl1, Ash 1, Ash1, Hash 1,Hash1, Mammalian achaete scute homolog 1, Mammalian achaete scute homologue 1, Mash 1, Mash1, Achaete-scute homolog 1.
Verfügbar in folgenden Ländern:worldwide

MASH1 is a transcription factor that is essential for the differentiation of neuroblasts and the generation of olfactory and autonomic neurons. MASH1 also regulates the cell cycle progression, including canonical cell cycle regulators and oncogenic transcription factors. MASH1 is highly specific for diagnosing high-grade, poorly differentiated neuroendocrine carcinomas. Its expression is observed in most pulmonary neuroendocrine tumors (small cell lung carcinoma and large cell neuroendocrine carcinoma), whereas non-small cell lung cancers (adenocarcinomas, squamous cell carcinomas, and large cell carcinomas) are rarely positive.