Lambda light chain

Rb, 1 ml Conc.

Artikelnummer:1-LA021-07
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Zelluläre Lokalisation:Cytoplasmic
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human Lambda Light Chain
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Kontrolle:Tonsil
Synonyme:Ig lambda chain C regions, Bence Jones protein, BJP, Constant region of lambda light chains, IGLC 1, IGLC 2, IGLC 3, IGLC, IGLC1, IGLC2, IGLC3, Immunoglobulin lambda constant 1, Mcg marker, Paraprotein.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two types of light chains designated as kappa and lambda. The lambda light chain antibody labels the lambda light chain that expresses normal and neoplastic B lymphocytes as well as plasma cells. Individual B cells express either kappa or lambda light chains. Monoclonality is generally assumed to be evidence of a malignant proliferation. The pairing of a kappa with a lambda light chain antibody is useful for identifying monoclonality of lymphoid malignancies.

Literatur

[1] StŒhlberg A, Aman P, Strömbom L et al. (2014): Comparison of reverse transcription quantitative real-time PCR, flow cytometry, and immunohistochemistry for detection of monoclonality in lymphomas. ISRN Oncol. 2014:796210.
[2] StŒhlberg A, Aman P, Ridell B et al. (2003): Quantitative real-time PCR method for detection of Blymphocyte monoclonality by comparison of kappa and lambda immunoglobulin light chain expression. Clin Chem. 49(1): 51-59.
[3] Levy R, Warnke R, Dorfman RF, Haimovich J (1977): The monoclonality of human B-cell lymphomas. J Exp Med. 145(4): 1014-1028.

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