Lambda light chain


Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human Lambda Light Chain
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Zelluläre Lokalisation:Cytoplasmic
Synonyme:Ig lambda chain C regions, Bence Jones protein, BJP, Constant region of lambda light chains, IGLC 1, IGLC 2, IGLC 3, IGLC, IGLC1, IGLC2, IGLC3, Immunoglobulin lambda constant 1, Mcg marker, Paraprotein.
Verfügbar in folgenden Ländern:worldwide

B lymphocytes produce immunoglobulins consisting of two identical heavy chains and either two identical kappa light chains or lambda light chains. Normal lymphoid tissues therefore contain a mixture of B cells that express kappa and lambda light chains in a ratio of 2:1. This ratio is lost in tumors of B cell origin as they arise from one transformed cell, and thus only one type of light chain is expressed. The monoclonality of malignant lymphoma is used as diagnostic marker in detection with Lambda Light Chain antibody.
This antibody labels lambda light chains of human immunoglobulins expressed by B lymphocytes and plasma cells. It may be helpful in detection of leukemia, plasmacytoma and various non-Hodgkin lymphoma. Other cells may also express lambda light chains resulting from non-specific immunoglobulin uptake. Lambda Light Chain antibody may be used in a panel with Kappa Light Chain.


[1] StŒhlberg A, Aman P, Strömbom L et al. (2014): Comparison of reverse transcription quantitative real-time PCR, flow cytometry, and immunohistochemistry for detection of monoclonality in lymphomas. ISRN Oncol. 2014:796210.
[2] StŒhlberg A, Aman P, Ridell B et al. (2003): Quantitative real-time PCR method for detection of Blymphocyte monoclonality by comparison of kappa and lambda immunoglobulin light chain expression. Clin Chem. 49(1): 51-59.
[3] Levy R, Warnke R, Dorfman RF, Haimovich J (1977): The monoclonality of human B-cell lymphomas. J Exp Med. 145(4): 1014-1028.