Lambda light chain
Rb, 1 ml RTU
Technische Daten
Lagerung AK: | Store at 2 - 8 °C. Do not use after expiration date indicated on the vial. | Kontrolle: | Tonsil | Zelluläre Lokalisation: | Cytoplasmic | Fixierung: | 1) NOTOXhisto 2) Formalin | Anwendung AK: | IHC(p),IHC(f) | Immunogen: | Synthetic peptide of human Lambda Light Chain | Ig Unterklasse: | IgG | Spezies: | Rabbit | Klon: | Polyclonal | Format AK: | Ready-to-use | Reaktivität AK: | Human, others not tested. | Synonyme: | Ig lambda chain C regions, Bence Jones protein, BJP, Constant region of lambda light chains, IGLC 1, IGLC 2, IGLC 3, IGLC, IGLC1, IGLC2, IGLC3, Immunoglobulin lambda constant 1, Mcg marker, Paraprotein. | Verfügbar in folgenden Ländern: | world wide (except US) | Status: | IVD |
Beschreibung
Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two types of light chains designated as kappa and lambda. The lambda light chain antibody labels the lambda light chain that expresses normal and neoplastic B lymphocytes as well as plasma cells. Individual B cells express either kappa or lambda light chains. Monoclonality is generally assumed to be evidence of a malignant proliferation. The pairing of a kappa with a lambda light chain antibody is useful for identifying monoclonality of lymphoid malignancies.
Literatur
[1] StŒhlberg A, Aman P, Strömbom L et al. (2014):
Comparison of reverse transcription quantitative real-time
PCR, flow cytometry, and immunohistochemistry for
detection of monoclonality in lymphomas. ISRN Oncol.
2014:796210.
[2] StŒhlberg A, Aman P, Ridell B et al. (2003):
Quantitative real-time PCR method for detection of Blymphocyte
monoclonality by comparison of kappa and
lambda immunoglobulin light chain expression. Clin
Chem. 49(1): 51-59.
[3] Levy R, Warnke R, Dorfman RF, Haimovich J (1977):
The monoclonality of human B-cell lymphomas. J Exp
Med. 145(4): 1014-1028.
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