Technische Daten
Status:Research Use Only (RUO)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human LEF-1
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Kontrolle:Tonsil tissue, small lymphocytic lymphoma
Change(s) made:Complete revision
Synonyme:lymphoid enhancing factor-1, Transcription factor T cell specific 1 alpha , DKFZp586H0919, LEF 1, LEF1, Lymphoid enhancer binding factor 1, T cell specific transcription factor 1 alpha, TCF 1 alpha, TCF1 alpha, TCF1alpha.
Verfügbar in folgenden Ländern:worldwide

LEF1 is a transcription factor playing crucial roles in WNT signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of this pathway is a cause of certain cancers, such as colon cancer, melanoma and breast cancer. LEF1 is expressed during development in many differentiating tissues, and in a few tissues after birth. Expression is required for proper development of breast, teeth, hair, whiskers, and the trigeminal nerve. LEF1 is found in the thymus, in colon cancer and several pancreatic tumors, but not in normal colon and only weakly in normal pancreatic tissue.