Kappa light chain


Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG
Immunogen:Purified human Kappa light chain
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092)
Zelluläre Lokalisation:Cytoplasmic, membranous
Kontrolle:Tonsil, lymph node
Synonyme:HCAK 1, HCAK1, Ig kappa chain C region, IGKC, Immunoglobulin kappa constant, , Immunoglobulin kappa constant region, Immunoglobulin kappa light chain, Kappa 1 immunoglobulin light chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809.
Verfügbar in folgenden Ländern:worldwide

B lymphocytes produce immunoglobulins consisting of two identical heavy chains and either two identical kappa light chains or lambda light chains. Normal lymphoid tissues therefore contain a mixture of B cells that express kappa and lambda light chains in a ratio of 2:1. This ratio is lost in tumors of B cell origin as they arise from one transformed cell, and thus only one type of light chain is expressed. The monoclonality of malignant lymphoma is used as diagnostic marker in detection with Kappa Light Chain antibody. This antibody labels kappa light chains of human immunoglobulins expressed by B lymphocytes and plasma cells. It may be helpful in detection of leukemia, plasmacytoma and various non-Hodgkin lymphoma. Other cells may also express kappa light chains resulting from non-specific immunoglobulin uptake. Kappa Light Chain antibody may be used in a panel with Lambda Light Chain.


[1] StŒhlberg A, Aman P, Strömbom L et al. (2014): Comparison of reverse transcription quantitative real-time PCR, flow cytometry, and immunohistochemistry for detection of monoclonality in lymphomas. ISRN Oncol. 2014:796210.
[2] StŒhlberg A, Aman P, Ridell B et al. (2003): Quantitative real-time PCR method for detection of Blymphocyte monoclonality by comparison of kappa and lambda immunoglobulin light chain expression. Clin Chem. 49(1): 51-59.
[3] Levy R, Warnke R, Dorfman RF, Haimovich J (1977): The monoclonality of human B-cell lymphomas. J Exp Med. 145(4): 1014-1028.