T cell immunoglobulin and mucin domain protein 1, also known as TIM1, KIM1, kidney injury molecule 1, HAVcr-1 or Hepatitis A virus cellular receptor 1, is a transmembrane glycoprotein that contributes to immune modulation, allergic response and viral disease susceptibility. It is widely expressed, and localized on the apical membrane. KIM-1 has been extensively evaluated in renal cell carcinoma (RCC) tissues, in lymph nodes to which tumors have metastasized, ovarian clear cell carcinoma and colorectal cancer.