INI-1

A-5, Ms

Artikelnummer:IN280-H_RUO
Menge:
Technische Daten
Change(s) made:Complete revision
Status:Research Use Only (RUO)
Spezies:Mouse
Ig Unterklasse:IgG1
Immunogen:Ini-1
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Kontrolle:Adrenal gland
Synonyme:Ini1/hSNF5/BAF47/SMARCB1
Verfügbar in folgenden Ländern:worldwide
Beschreibung

Integrase interactor 1 (INI1/hSNF5) is a core component of the SWI/SNF chromatin remodeling complex that alters the structure of chromatin in order to facilitate DNA-dependent cellular processes like transcription, replication, and repair. Biallelic loss-of-function of INI1/hSNF5 leads to certain cancers, most frequently rhabdoid tumors, demonstrating that INI1/hSNF5 is a tumor suppressor gene. INI1/hSNF5 regulates several essential steps in the propagation of the HIV-1 virus within the host cell, particularly HIV-1 integration. The mode of function of INI1/hSNF5 is only beginning to be understood.

Literatur

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